Chronic inflammation and oxidative stress are thought to play significant roles in the onset and progression of a number of chronic diseases. Orange juice has been associated with beneficial impacts on a number of inflammatory and oxidative stress markers. The consumption of 750 mL of orange juice for 8 weeks as part of the usual diet was associated with improvements in some anti-inflammatory and oxidative stress markers in men and women.(Dourado) A study in 12 healthy men and women reported that daily consumption of 500 mL of orange juice for 2 weeks resulted in a significant reduction in 8-epiPGF2α, a marker for oxidative stress.(Sanchez-Moreno) Two clinical studies demonstrated that the consumption of orange juice helped attenuate the inflammatory response caused by the consumption of a high carbohydrate and/or high fat meal.(Cerletti, Ghanim) There was no significant effect on inflammatory markers in men who consumed 8 ounces of orange juice daily for 12 weeks as part of their usual diet.(Simpson)
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