Metabolic syndrome is a group of risk factors that include central (waist) obesity, elevated triglycerides and fasting blood glucose, elevated blood pressure, and low HDL cholesterol. Several of these factors occurring together may increase the risk for conditions such as type 2 diabetes, heart disease or stroke. Diabetes is a disease that results from the body’s inability to produce or use insulin.

A clinical study reported that young and middle-aged overweight women who consumed about 8 ounces of 100% orange juice daily for 12 weeks demonstrated no adverse effects on measures of insulin sensitivity, body composition, or other indices of the metabolic syndrome.(Simpson) Another clinical study reported no adverse impact of the consumption of 500 mL of  orange juice daily for 4 weeks on markers of glucose or insulin metabolism.(Morand)

Epidemiological studies reported no association between orange or grapefruit juice intake and diabetes incidence in a cohort of almost 44,000 African American women,(Palmer) and no association between the intake of fruit juice and diabetes incidence in the Nurses’ Health Study cohort.(Schulze) A longitudinal study in over 24,000 residents of the United Kingdom reported that fruit juice intake was not associated with the incidence of type 2 diabetes in men or women.(O’Connor)

A meta-analysis of randomized controlled trials concluded that fruit juice intake had no significant effect on fasting glucose and insulin in adults(Wang) and a meta-analysis of prospective cohort studies concluded that the intake of 100% fruit juice was not associated with the risk of developing type 2 diabetes in adults.(Xi)

References
Morand C et al. Am J Clin Nutr. 2011;93:73–80.
O’Connor L et al. Diabetologia. 2015;658:1474-1483.
Palmer JR et al. Arch Intern Med. 2008;28;168):1487-1492.

Schulze MB et al. JAMA. 2004;292:927-934.
Simpson EJ et al. Food Func. 2016;7:1884-1891.
Wang B et al. PLoS ONE. 2014;9:e95323.
Xi B et al. PLoS ONE. 2014;9:e93471.