How Does 100% Orange Juice Support Your Immune System?
Orange juice can help support a strong immune system by providing a variety of vitamins and nutrients.
- Vitamin C is commonly associated with helping maintain a healthy immune system and is abundant in 100% orange juice. Vitamin C strengthens our immune systems by protecting cells and promoting the production and function of immune cells. One 8-ounce glass of OJ provides 90-140% of your recommended Daily Value, making orange juice an excellent source of vitamin C.*
- Vitamin D plays an important role in regulating our immune responses and helps immune cells fight off bacteria and viruses that get into the body. Fortified orange juice is a good source of vitamin D, providing 15% of the Daily Value in an 8-ounce glass.*
- Beneficial plant compounds, flavonoids and colorful carotenoids, work to support the immune system by fighting inflammation and helping cells communicate with each other. Improving cell communication can help boost our immune response when encountering infection. 100% orange juice has many beneficial plant compounds which support a healthy immune system.
Learn more about how you can support your immune system here.
Vitamin C may help support a healthy immune system and citrus juices are reported to be a major contributor of vitamin C in the diet. 1
Detailed Nutrition Information
Vitamin C behaves as an antioxidant by scavenging Reactive Oxidative Species (ROS) and works with powerful antioxidant enzymes in the body and with vitamins (e.g. glutathione, vitamin E).2-4 Vitamin C is particularly important to the immune system as it stimulates the production and function of white blood cells and protects cells against ROS that are generated from activation of white blood cells as a result of infection and inflammatory stress.3-4
Histamine is a compound released by cells in response to allergic and inflammatory reactions. It’s involved in the presentation of symptoms such as nasal stuffiness, runny nose, teary eyes, and coughing. Vitamin C is thought to have an anti-histamine effect,5 which may help lessen cold symptom severity.4,6
Results from some studies show that immune functions improve with increased vitamin C intake, while other studies show no effect. The inconsistency may be due to the use of adequately nourished study participants, or because leukocytes saturate with vitamin C at a lower intake than is required to saturate plasma (~100 mg/day).4
In a Cochrane review and meta-analysis combining 29 studies,7 prophylactic vitamin C supplementation reduced the incidence of colds by 52% in participants undergoing heavy physical stress (e.g., marathon runners, soldiers in subarctic conditions, skiers), while the effect was not significant in the pooled general community trials (RR 0.97 (0.94 to 1.00). Vitamin C administration also reduced cold duration by 14% in children and 8% in adults, and reduced cold severity in 31 comparisons of 9,745 cold episodes. However, therapeutic trials were inconsistent in these effects.
Vitamin D strongly modulates the immune system. Many immune cells express vitamin D–activating enzymes allowing them to convert vitamin D precursors to the active form of vitamin D.8 This promotes antibacterial responses to pathogens by modulating CD4+ T-cell functions and allows epithelial cells to mount an antibacterial response.8
Multiple studies have found associations between low vitamin D and increased risk of infections, including influenza and other respiratory infections and sepsis.8 Several meta-analyses have shown mixed results regarding the effectiveness of vitamin D supplementation and improved resistance to respiratory infection. However, many other studies showed positive benefits of vitamin D on respiratory infection, particularly in people with low vitamin D status.8
Fortified orange juice varieties often provide vitamin D along with calcium needed for strong bones.
Bioactive Plant Compounds
Many carotenoids found in 100% orange juice, including beta-carotene, alpha-carotene and beta-cryptoxanthin, can form vitamin A in the body which is important for immune function.9 Vitamin A is necessary for epithelial cell health, gene expression and immune function.10 Carotenoids have shown to have antioxidant properties and help reduce inflammation, as well as aid in the immune system.9,10 Hundreds of studies have shown carotenoids from foods (found in high amounts in fruits and vegetables) to be associated with lower risk of many diseases including macular degeneration, cardiovascular disease and many cancers including of the prostate, breast, cervix and lung.9,11
Research supports the role of flavonoids in the immune system. In human clinical studies, hesperidin in orange juice exerted positive changes in antioxidant enzymes, altered white blood cell gene expression to anti-inflammatory profiles, and lowered oxidative stress biomarkers that protect against DNA damage and lipid peroxidation.12,13 A systematic review of randomized controlled trials testing flavonoids’ effects on the respiratory and immune system function found that among those who consumed flavonoids, there was a 33% decrease in upper respiratory tract infections in comparison to those who did not consume flavonoids.14
The flavonoid hesperidin is highly concentrated in citrus and rarely found in other foods,15 making orange juice a unique source.
Consider including nutrient-rich Florida Orange Juice in your daily diet. Working to maintain a healthier immune system is also a great way to help you get through cold and flu season. Florida Orange Juice may also help keep you hydrated when you’re on your way to feeling better.
* Values based on a 2000 calorie diet. FDA rounding rules applied when calculating percent DV based upon 2018 rules. Information is not intended for labeling food in packaged form. USDA SR28 database entries for 90206 and 09209 were used for calculating RDI.
- Chun et al. J Nutr. 2010;140:317-324.
- Lykkesfeldt et al. Adv Nutr 2014; 5:16-18.
- Vitamin C. Linus Pauling Institute Micronutrient Information Center. Oregon State University. http://lpi.oregonstate.edu/mic/vitamins/vitamin-C).
- Food and Nutrition Board, Institute of Medicine. Vitamin C. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, D.C.: National Academy Press; 2000:95-185.
- Vitamin C Fact Sheet for Health Professionals. Office of Dietary Supplements. National Institutes of Health. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
- Johnston et al. Subcell Biochem 1996;25:189-213.
- Hemila et al. Cochrane Database Syst Rev. 2013(1):Cd000980.
- Lang et al. Clin Thera. 2017; 39(5):930-945.
- Carotenoids, In: Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Institute of Medicine. The National Academies Press, Washington, DC. 2000.
- Vitamin A, In: Dietary Reference Intakes. Institute of Medicine. The National Academies Press, Washington, DC. 2006
- Carotenoids. Linus Pauling Institute. Oregon State University. http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/carotenoids
- Rangel-Huerta et al. J Nutr. 2015;145(8):1808-1816.
- Milenkovic , PLoS One. 2011;6(11):e26669.
- Somerville, Adv Nutr. 2016;7(3):488-497.
- Bhagwat S, Haytowitz D. USDA Database for the Flavonoid Content of Selected Foods Release 3.2. In. Beltsville, MD: Unites States Department of Agriculture; 2015.